Comparison between different first-line therapy protocols of eradicating Helicobacter pylori in children / 中国小儿急救医学

ABSTRACT

Objective To determine the efficacy of different first-line regimens for Helicobacter pylori(Hp) eradication,and to suggest an alternative first-line therapy particularly in children.Methods One hundred and twenty-four patients who diagnosed as peptic ulcer or chronic gastritis by gastroscope with Hp infection were included and randomly divided into four groups,each receiving different first-line eradication therapy.A groupstandard triple therapy for 10 days;B groupstandard triple therapy for 14 days;C grouptriple therapy containing bismuth agent;D groupsequential therapy.The eradication rates of Hp and adverse event rates in four groups were compared.Results The highest eradication rate was in D group (90.9％,P ＜ 0.05),there was no significant difference between the other three groups (P ＞ 0.05).The main adverse reactions during treatment were abdominal pain,fullness,nausea and vomiting.Among them,adverse event rate was the highest in C group (41.4％,P ＜ 0.05),there was no significant difference between the other three groups (P ＞ 0.05).Conclusion The sequential therapy is significantly more effective than standard triple therapy and triple therapy containing bismuth agent.Adverse event rate is the highest in the triple therapy containing bismuth agent.