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The research progress of p38 MAPK and allergic rhinitis / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 2094-2098, 2015.
Article in Chinese | WPRIM | ID: wpr-746816
ABSTRACT
Allergic rhinitis is a kind of nasal mucosal chronic noninfectious inflammatory disease, which is caused by an imbalance in the body cytokine network,a number of intracellular signaling pathways being actived. Many studies have shown that mitogen-activated protein kinase (MAPK) involved in the activation process of allergic rhinitis. p38 mitogen-activated protein kinase (MAPK), as one kind of that, plays a key role in the process of inflammatory cells proliferation and differentiation, as well as production of inflammatory cytokines, and involved in airway inflammatory mechanisms of chronic airway disease. In vitro experiments have confirmed that p38 MAPK inhibitors have anti-inflammatory effect by blocking the downstream related response.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Cell Differentiation / Cytokines / MAP Kinase Signaling System / P38 Mitogen-Activated Protein Kinases / Cell Proliferation / Rhinitis, Allergic / Inflammation / Metabolism Limits: Humans Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Cell Differentiation / Cytokines / MAP Kinase Signaling System / P38 Mitogen-Activated Protein Kinases / Cell Proliferation / Rhinitis, Allergic / Inflammation / Metabolism Limits: Humans Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2015 Type: Article