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Correlation and regression analysis of fetal facial angles at 11-38 weeks of pregnancy with gestational age / 中华超声影像学杂志
Chinese Journal of Ultrasonography ; (12): 307-312, 2019.
Article in Chinese | WPRIM | ID: wpr-754803
ABSTRACT
Objective To determine the fetal facial angles at 11 -38 weeks of gestation by three‐dimensional ultrasound ( 3DUS) and analyze the correlation between facial angles and gestational age( GA ) . Methods From 2013 April to 2014 February ,439 singleton fetuses ranged 11-38 weeks of gestation were enrolled in this study . T he details of mid‐sagittal plane of facial profile was confirmed with 3DUS . Four facial angels were measured in this plane ,including frontomaxillary facial angle ( FM F ) ,frontonasal angle ( FNA ) ,mandibulomaxillary facial angle( M M F) and maxilla‐nasion‐mandible angle( M NM ) . T he intra‐and interobserver reliability were calculated in first 30 cases ,intra‐class correlation coefficient( ICC) greater than 0 .75 indicated good reliability . Pearson′s correlation coefficient ( r ) ,curve estimation and polynomial regression models were used to evaluate the correlation of the fetal facial angles with GA . Results ICC of the same observer were 0 .968 ,0 .962 ,0 .974 and 0 .988 ,respectively . ICC of different observer were 0 .948 , 0 .905 ,0 .874 and 0 .889 ,respectively . T he fetal facial angles of FM F ,FNA ,M M F and M NM showed correlations with GA ( r = -0 .369 ,0 .447 ,-0 .470 ,0 .386 ; all P =0 .000) . Using GA as the independent variable and the facial angles as the dependent variables , the best fit regressing equation was cubic polynomialFM F=135 .300-6 .473×GA+0 .235×GA2 -0 .003×GA3 ( R2 =0 .240 , P =0 .000 ) ;FNA=58 .920+7 .452×GA -0 .274×GA2 -0 .003×GA3 ( R2 =0 .297 , P =0 .000 ) ;M M F=132 .329 -5 .337× GA+0 .191× GA2 -0 .002× GA3 ( R2 = 0 .304 , P = 0 .000) ;M NM = -24 .592+ 4 .653× GA -0 .173× GA2 + 0 .002 × GA3 ( R2 = 0 .413 , P = 0 .000 ) . Conclusions The development of fetal facial angles are related to GA . T he growing patterns of fetal facial angles fit with a cubic polynomial function .

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Ultrasonography Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Ultrasonography Year: 2019 Type: Article