Factors influencing antibiotics dosage adjustment in continuous renal replacement therapy / 中华全科医师杂志

ABSTRACT

Continuous renal replacement therapy (CRRT) will eliminate antibiotics while eliminating water and solutes from the body,so adjusting antibiotics dose timely is important for patients undergoing CRRT.Pharmacological characteristics of antimicrobials,pathological and physiological statues of the patients,effects of CRRT on antibiotics clearance and other factors would affect the pharmacokinetics of antibiotics.In order to achieve the desired therapeutic effect,the monitoring of drug concentration and individualizing the dosage of antibiotics are cecessary.