Molecular guidance cues in the development of visual pathway
Protein & Cell
; (12): 909-929, 2018.
Article
in En
| WPRIM
| ID: wpr-758007
Responsible library:
WPRO
ABSTRACT
70%-80% of our sensory input comes from vision. Light hit the retina at the back of our eyes and the visual information is relayed into the dorsal lateral geniculate nuclei (dLGN) and primary visual cortex (V1) thereafter, constituting the image-forming visual circuit. Molecular cues are one of the key factors to guide the wiring and refinement of the image-forming visual circuit during pre- and post-embryonic stages. Distinct molecular cues are involved in different developmental stages and nucleus, suggesting diverse guidance mechanisms. In this review, we summarize molecular guidance cues throughout the image-forming visual circuit, including chiasm determination, eye-specific segregation and refinement in the dLGN, and at last the reciprocal connections between the dLGN and V1.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Visual Cortex
/
Visual Pathways
/
Geniculate Bodies
/
Metabolism
Type of study:
Guideline
Limits:
Animals
/
Humans
Language:
En
Journal:
Protein & Cell
Year:
2018
Type:
Article