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Intra-articular Recombinant Human Growth Hormone Injection Compared with Hyaluronic Acid and Placebo for an Osteoarthritis Model of New Zealand Rabbits
The Journal of Korean Knee Society ; : 44-53, 2019.
Article in English | WPRIM | ID: wpr-759357
ABSTRACT

PURPOSE:

Up to now, there is no feasible solution for stopping or reversing the degenerative process of osteoarthritis (OA). Our study evaluated the effect of intra-articular injection of growth hormone (GH) in OA-induced rabbit knees compared to hyaluronic acid (HA) and placebo. MATERIALS AND

METHODS:

A total of 21 male, skeletally mature, New Zealand rabbits received an intra-articular type II collagenase injection for OA induction. Two weeks later, the rabbits were randomized into three groups based on the weekly intra-articular injection to be received GH, HA, and saline. Injections were done for three consecutive weeks. Evaluation was done at 8 weeks after treatment, clinically using the lameness period, macroscopically using the Yoshimi score and microscopically using the Mankin score.

RESULTS:

The shortest period of lameness was found in the GH group (15.9±2.12 days), compared to the HA group (19.4±1.72 days) and placebo group (25.0±2.94 days). There was a statistically significant difference in macroscopic scoring between groups (p=0.001) in favor of the GH group. There was also significant difference in the microscopic score between groups (p=0.001) also in favor of the GH group.

CONCLUSIONS:

Intra-articular injection of GH showed better clinical, macroscopic and microscopic results as compared to HA and placebo.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteoarthritis / Growth Hormone / Collagenases / Human Growth Hormone / Hyaluronic Acid / Injections, Intra-Articular / Knee / New Zealand Type of study: Controlled clinical trial / Prognostic study Limits: Animals / Humans / Male Country/Region as subject: Oceania Language: English Journal: The Journal of Korean Knee Society Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteoarthritis / Growth Hormone / Collagenases / Human Growth Hormone / Hyaluronic Acid / Injections, Intra-Articular / Knee / New Zealand Type of study: Controlled clinical trial / Prognostic study Limits: Animals / Humans / Male Country/Region as subject: Oceania Language: English Journal: The Journal of Korean Knee Society Year: 2019 Type: Article