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Associations for BCO2, PCSK9, and TR1B1 Polymorphism and Lifestyle Factors with Ischemic Stroke: A Nested Case-Control Study
Yonsei Medical Journal ; : 659-666, 2019.
Article in English | WPRIM | ID: wpr-762094
ABSTRACT

PURPOSE:

To investigate associations for polymorphisms in β-carotene 9′,10′-oxygenase (BCO2, rs10431036 and rs11214109), proprotein convertase subtilisin kexin type 9 (PCSK9, rs11583680), and tribbles pseudokinase 1 (TRIB1, rs17321515 and rs2954029), as well as lifestyle factors, with ischemic stroke (IS). MATERIALS AND

METHODS:

This nested case-control study included 161 patients with IS and 483 matched control individuals. We collected medical reports, lifestyle details, and blood samples from individuals and used the PCR-ligase detection reaction method to genotype single nucleotide polymorphisms (SNPs).

RESULTS:

The GA+AA genotype of rs10431036 (p<0.001) and rs17321515 (p=0.003), the CT+TT genotype of rs11214109 (p=0.005), and the TA+AA genotype of rs2954029 (p=0.006) in dominant models increased the risk of IS. In additive models, the GG genotype of rs17321515 (p=0.005) and the TT genotype of rs2954029 (p=0.008) increased the risk of IS. Adequate intake of fruits/vegetables reduced the risk of IS (p=0.005). Although there was no interaction between genes and fruits/vegetables, people with inadequate intake of fruits/vegetables who carried a risk genotype had a higher risk of IS than those only having inadequate fruits/vegetables intake or those only carrying a risk genotype. Also, the haplotypes AC, AT, and GT (comprising rs10431036 and rs11214109) and GT (comprising rs2954029 and rs17321515) were found to be associated with an increased risk of IS (p<0.05).

CONCLUSION:

Polymorphisms in BCO2 and TRIB1 and fruits/vegetables intake were associated with IS. These results provide the theoretical basis for gene screening to prevent chronic cerebrovascular diseases.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Haplotypes / Case-Control Studies / Cerebrovascular Disorders / Mass Screening / Stroke / Subtilisin / Polymorphism, Single Nucleotide / Proprotein Convertases / Genotype / Life Style Type of study: Observational study / Prognostic study / Risk factors / Screening study Limits: Humans Language: English Journal: Yonsei Medical Journal Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Haplotypes / Case-Control Studies / Cerebrovascular Disorders / Mass Screening / Stroke / Subtilisin / Polymorphism, Single Nucleotide / Proprotein Convertases / Genotype / Life Style Type of study: Observational study / Prognostic study / Risk factors / Screening study Limits: Humans Language: English Journal: Yonsei Medical Journal Year: 2019 Type: Article