The correlation between serum vascular endothelial growth factor (VEGF) and tumor VEGF receptor 3 in colorectal cancer
Annals of Surgical Treatment and Research
;
: 15-20, 2019.
Article
in English
| WPRIM
| ID: wpr-762682
ABSTRACT
PURPOSE:
Despite plasma biomarkers offering a number of advantages over tissue-based markers, the relationship between serum vascular endothelial growth factor (VEGF) and VEGF receptor (VEGF-R) tumor expression in colorectal cancer (CRC) is still unclear. This study was designed to establish the relationship between the concentration of serum VEGF and tumor VEGF-R expression in patients with CRC.METHODS:
A prospective study of consecutive patients undergoing elective colorectal surgery during 1 year. Preoperative VEGF was determined by enzyme-linked immunosorbent assay and VEGF-R3 by immunochemistry.RESULTS:
The initial sample included 134 patients with CRC diagnosis. Results showed significant association of serum values of VEGF with VEGF-R3 expression (P < 0.001), even in the presence of confounders (sex, age, body mass index, tumor location, and surgical approach). The estimated effect size was high (η² = 0.35).CONCLUSION:
Serum VEGF has a significant correlation with tumoral VEGF-R3 expression in CRC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Enzyme-Linked Immunosorbent Assay
/
Immunohistochemistry
/
Immunochemistry
/
Biomarkers
/
Colorectal Neoplasms
/
Body Mass Index
/
Prospective Studies
/
Colorectal Surgery
/
Receptors, Vascular Endothelial Growth Factor
Type of study:
Diagnostic study
/
Observational study
Limits:
Humans
Language:
English
Journal:
Annals of Surgical Treatment and Research
Year:
2019
Type:
Article
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