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The correlation between serum vascular endothelial growth factor (VEGF) and tumor VEGF receptor 3 in colorectal cancer
Annals of Surgical Treatment and Research ; : 15-20, 2019.
Article in English | WPRIM | ID: wpr-762682
ABSTRACT

PURPOSE:

Despite plasma biomarkers offering a number of advantages over tissue-based markers, the relationship between serum vascular endothelial growth factor (VEGF) and VEGF receptor (VEGF-R) tumor expression in colorectal cancer (CRC) is still unclear. This study was designed to establish the relationship between the concentration of serum VEGF and tumor VEGF-R expression in patients with CRC.

METHODS:

A prospective study of consecutive patients undergoing elective colorectal surgery during 1 year. Preoperative VEGF was determined by enzyme-linked immunosorbent assay and VEGF-R3 by immunochemistry.

RESULTS:

The initial sample included 134 patients with CRC diagnosis. Results showed significant association of serum values of VEGF with VEGF-R3 expression (P < 0.001), even in the presence of confounders (sex, age, body mass index, tumor location, and surgical approach). The estimated effect size was high (η² = 0.35).

CONCLUSION:

Serum VEGF has a significant correlation with tumoral VEGF-R3 expression in CRC.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma / Enzyme-Linked Immunosorbent Assay / Immunohistochemistry / Immunochemistry / Biomarkers / Colorectal Neoplasms / Body Mass Index / Prospective Studies / Colorectal Surgery / Receptors, Vascular Endothelial Growth Factor Type of study: Diagnostic study / Observational study Limits: Humans Language: English Journal: Annals of Surgical Treatment and Research Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma / Enzyme-Linked Immunosorbent Assay / Immunohistochemistry / Immunochemistry / Biomarkers / Colorectal Neoplasms / Body Mass Index / Prospective Studies / Colorectal Surgery / Receptors, Vascular Endothelial Growth Factor Type of study: Diagnostic study / Observational study Limits: Humans Language: English Journal: Annals of Surgical Treatment and Research Year: 2019 Type: Article