The mechanisms and treatments of muscular pathological changes in immobilization-induced joint contracture: A literature review / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 93-98, 2019.
Article
in English
| WPRIM
| ID: wpr-771633
ABSTRACT
The clinical treatment of joint contracture due to immobilization remains difficult. The pathological changes of muscle tissue caused by immobilization-induced joint contracture include disuse skeletal muscle atrophy and skeletal muscle tissue fibrosis. The proteolytic pathways involved in disuse muscle atrophy include the ubiquitin-proteasome-dependent pathway, caspase system pathway, matrix metalloproteinase pathway, Ca-dependent pathway and autophagy-lysosomal pathway. The important biological processes involved in skeletal muscle fibrosis include intermuscular connective tissue thickening caused by transforming growth factor-β1 and an anaerobic environment within the skeletal muscle leading to the induction of hypoxia-inducible factor-1α. This article reviews the progress made in understanding the pathological processes involved in immobilization-induced muscle contracture and the currently available treatments. Understanding the mechanisms involved in immobilization-induced contracture of muscle tissue should facilitate the development of more effective treatment measures for the different mechanisms in the future.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Atrophy
/
Autophagy
/
Therapeutics
/
Fibrosis
/
Signal Transduction
/
Calcium
/
Muscle, Skeletal
/
Connective Tissue
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Traumatology
Year:
2019
Type:
Article
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