Application of metabolic network model to analyze intracellular metabolism of industrial microorganisms / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1901-1913, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-771744
ABSTRACT
To quickly and efficiently understand the intracellular metabolic characteristics of industrial microorganisms, and to find potential metabolic engineering targets, genome-scale metabolic network models (GSMMs) as a systems biology tool, are attracting more and more attention. We review here the 20-year history of metabolic network model, analyze the research status and development of GSMMs, summarize the methods for model construction and analysis, and emphasize the applications of metabolic network model for analyzing intracellular metabolic activity of microorganisms from cellular phenotypes, and metabolic engineering. Furthermore, we indicate future development trend of metabolic network model.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Industrial Microbiology
/
Systems Biology
/
Metabolic Networks and Pathways
/
Metabolic Engineering
/
Genetics
/
Models, Biological
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2019
Type:
Article
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