Oral microbiological diversity in patients with salivary adenoid cystic carcinoma / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 304-308, 2019.
Article
in Zh
| WPRIM
| ID: wpr-772656
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#The aim of this study was to identify the differences in microbial diversity and community in patients with salivary adenoid cystic carcinoma (SACC).@*METHODS@#Saliva was collected from 13 patients with SACC confirmed by histopathological diagnosis and 10 healthy control subjects. Total metagenomic DNA was extracted. The DNA amplicons of the V3-V4 hypervariable regions of the 16S rRNA gene were generated and subjected to high-throughput sequencing. Microbial diversity and community structure were analyzed with Mothur software.@*RESULTS@#A total of 16 genera of dominant bacteria in the SACC group were found, including Streptococcus (36.68%), Neisseria (8.55%), Prevotella_7 (7.53%), and Veillonella (6.37%), whereas 15 dominant bacteria in the control group were found, including Streptococcus (18.41%), Neisseria (18.20%), Prevotella_7 (8.89%), Porphyromonas (6.20%), Fusobacterium (5.86%) and Veillonella (5.82%). The statistically different phyla between the two groups were Firmicutes, Proteobacteria and Fusobacterium (P<0.05). The statistically different genera between the two groups were Streptococcus, Neisseria and Porphyromonas (P<0.05), and Capnocytophaga was only detected in patients with SACC.@*CONCLUSIONS@#Significant differences were observed in the oral microorganisms between the two groups.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Saliva
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Bacteria
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Salivary Gland Neoplasms
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RNA, Ribosomal, 16S
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Porphyromonas
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Carcinoma, Adenoid Cystic
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Microbiology
Limits:
Humans
Language:
Zh
Journal:
West China Journal of Stomatology
Year:
2019
Type:
Article