Effect of IL-8 on the Immune Function of Patients with Acute -Lymphoblastic Leukemia and Its Mechanism / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1621-1625, 2018.
Article
in Zh
| WPRIM
| ID: wpr-773046
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the effect of interleukin -8 (IL-8) on immune function in acute lymphoblastic leukemia patients and its related mechanisms.@*METHODS@#Forty-five ALL patients were selected from January 2014 to September 2017 in our hospital. Out of them, 32 relieved patients were included in group A, 13 patients did not relieved patients after treatment and were included in the group B. The serum IL-8 level was detected by ELISA.Th1 and Th2 cells were measured by flow cytometry. After Th cells were treated with different concentration of IL-8, the Western blot was used to detect the translation levels of p-STAT3 and JAK in cells.@*RESULTS@#The difference of white blood cell count and clinical risk level between the 2 groups was statistically significant (P0.05).@*CONCLUSION@#IL-8 can interfere the balance of Th1/Th2 through STAT3 signaling pathway, and has effect on the immune function of ALL patients.
Full text:
1
Index:
WPRIM
Main subject:
Interleukin-8
/
Interferon-gamma
/
Th2 Cells
/
Th1 Cells
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2018
Type:
Article