Progress on correlation between cell senescence and idiopathic pulmonary fibrosis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 111-115, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-775247
ABSTRACT
Cellular senescence is a key factor driving age-related diseases. Recent studies have revealed that senescence-associated secretory phenotype, telomere attrition, epigenetic changes, and mitochondrial autophagy damage may mediate the pathogenesis of senescence-related idiopathic pulmonary fibrosis (IPF). Reducing the level of cellular senescence or clearing senescent cells can down-regulate the expression of fibrosis factors and alleviate the symptoms of IPF. In this review, we outlined the role and mechanism of cellular senescence in IPF.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autophagy
/
Gene Expression
/
Cellular Senescence
/
Epigenesis, Genetic
/
Idiopathic Pulmonary Fibrosis
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2019
Type:
Article
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