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Progress on correlation between cell senescence and idiopathic pulmonary fibrosis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 111-115, 2019.
Article in Chinese | WPRIM | ID: wpr-775247
ABSTRACT
Cellular senescence is a key factor driving age-related diseases. Recent studies have revealed that senescence-associated secretory phenotype, telomere attrition, epigenetic changes, and mitochondrial autophagy damage may mediate the pathogenesis of senescence-related idiopathic pulmonary fibrosis (IPF). Reducing the level of cellular senescence or clearing senescent cells can down-regulate the expression of fibrosis factors and alleviate the symptoms of IPF. In this review, we outlined the role and mechanism of cellular senescence in IPF.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Autophagy / Gene Expression / Cellular Senescence / Epigenesis, Genetic / Idiopathic Pulmonary Fibrosis Limits: Humans Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Autophagy / Gene Expression / Cellular Senescence / Epigenesis, Genetic / Idiopathic Pulmonary Fibrosis Limits: Humans Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2019 Type: Article