Phosphorylated TDP-43 Staging of Primary Age-Related Tauopathy / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 183-192, 2019.
Article
in En
| WPRIM
| ID: wpr-775460
Responsible library:
WPRO
ABSTRACT
Primary age-related tauopathy (PART) is characterized by tau neurofibrillary tangles (NFTs) in the absence of amyloid plaque pathology. In the present study, we analyzed the distribution patterns of phosphorylated 43-kDa TAR DNA-binding protein (pTDP-43) in the brains of patients with PART. Immunohistochemistry and immunofluorescence double-labeling in multiple brain regions was performed on brain tissues from PART, Alzheimer's disease (AD), and aging control cases. We examined the regional distribution patterns of pTDP-43 intraneuronal inclusions in PART with Braak NFT stages > 0 and ≤ IV, and a Thal phase of 0 (no beta-amyloid present). We found four stages which indicated potentially sequential dissemination of pTDP-43 in PART. Stage I was characterized by the presence of pTDP-43 lesions in the amygdala, stage II by such lesions in the hippocampus, stage III by spread of pTDP-43 to the neocortex, and stage IV by pTDP-43 lesions in the putamen, pallidum, and insular cortex. In general, the distribution pattern of pTDP-43 pathology in PART cases was similar to the early TDP-43 stages reported in AD, but tended to be more restricted to the limbic system. However, there were some differences in the distribution patterns of pTDP-43 between PART and AD, especially in the dentate gyrus of the hippocampus. Positive correlations were found in PART between the Braak NFT stage and the pTDP-43 stage and density.
Key words
Full text:
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Index:
WPRIM
Main subject:
Pathology
/
Severity of Illness Index
/
Brain
/
Aging
/
Immunohistochemistry
/
Inclusion Bodies
/
Neurofibrillary Tangles
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Disease Progression
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Tauopathies
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DNA-Binding Proteins
Limits:
Aged
/
Aged80
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Female
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Humans
/
Male
Language:
En
Journal:
Neuroscience Bulletin
Year:
2019
Type:
Article