Functions of lamin B1 and the new progress of its roles in neurological diseases and tumors / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1742-1749, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-776294
ABSTRACT
Lamin B1 is one of the essential members of the nuclear lamina protein family. Its main function is to maintain the integrity of nuclear skeleton, as well as to participate in the cell proliferation and aging by affecting the chromosome distribution. gene expression, and DNA damage repair. The abnormal expression of lamin B1 is related to certain diseases, including neurological diseases [e.g. neural tube defects (NDTs), adult-onset autosomal dominant leukodystrophy (ADLD)] and tumors (e.g. pancreatic cancer). It is also a potential tumor marker as well as drug target. Further research on lamin B1 will help people understand the molecular mechanism of the emergence and development of neural system diseases and tumors, and define a new future in drug target.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Gene Expression
/
Cell Nucleus
/
Lamin Type B
/
Neoplasms
/
Nervous System Diseases
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2018
Type:
Article
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