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Prognostic Analysis of Lobectomy versus Sublobar Resection in Patients Aged ≥60 Years with Stage Ia Small Cell Lung Cancer / 中国肺癌杂志
Chinese Journal of Lung Cancer ; (12): 8-15, 2018.
Article in Chinese | WPRIM | ID: wpr-776384
ABSTRACT
BACKGROUND@#Currently, the prognosis of lobectomy and sub-lobectomy for the treatment of stage Ia small cell lung cancer (SCLC) is rarely reported. We retrospectively studied T1N0M0 (≤3 cm) SCLC patients aged ≥60 years, aiming to comparatively analyze the prognosis of lobectomy and sub-lobectomy in treating patients with Ia SCLC.@*METHODS@#Patients with stage Ia SCLC diagnosed by pathologic between 1992 and 2010 were selected from the "Surveillance, Epidemiology and End Results database"(SEER). Outcome data were compared using Kaplan-Meier (Log-rank test) and Cox model multivariate analysis.@*RESULTS@#We identified 515 patients. Median overall survival (OS) of the lobectomy (n=110), sublobar resection (n=57) and non-surgical (n=348) cohort were 45, 23 and 16 months, respectively. The corresponding 5-year OS of the three groups were 44%, 30%, and 14%, respectively. No significant difference in the prognosis of patients with or without lymph node examination/ dissection (P=0.107) and the 5-year OS of patients underwent lobectomy with chemoradiation was 50%. Cox multivariable analysis showed that operation treatment, including lobectomy and sublobectomy, was one of the independent factors associated with the prognosis of early SCLC patients, and patients undergo lobectomy shows a better OS compared with sublobar resection (Lob vs Sub, HR=0.645; 95%CI 0.433-0.961, P=0.031).@*CONCLUSIONS@#For age ≥60 years T1N0M0 (≤3 cm) SCLC patients, we recommend anatomical lobectomy combined with adjuvant chemoradiation.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pneumonectomy / Prognosis / General Surgery / Retrospective Studies / Diagnosis / Small Cell Lung Carcinoma / Lung Neoplasms Type of study: Diagnostic study / Observational study / Prognostic study Limits: Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Lung Cancer Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pneumonectomy / Prognosis / General Surgery / Retrospective Studies / Diagnosis / Small Cell Lung Carcinoma / Lung Neoplasms Type of study: Diagnostic study / Observational study / Prognostic study Limits: Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Lung Cancer Year: 2018 Type: Article