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Roles of integrin in tumor development and the target inhibitors / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 241-251, 2019.
Article in English | WPRIM | ID: wpr-776888
ABSTRACT
Integrin is a large family of cell adhesion molecules (CAMs) which involves in the interaction of cells/cells and cells/ extracellular matrix (ECM) to mediate cell proliferation, differentiation, adhesion, migration, etc. In recent years, aberrant expression of integrin has been clearly found in many tumor studies, indicating that integrin is closely related to tumor formation and development. Meanwhile, it has effects on tumor cell differentiation, cell migration, proliferation and tumor neovascularization. The study of drugs targeting integrins is of great significance for the clinical treatment of tumors. Because of its important role in tumorigenesis and development, integrin has become a promising target for the treatment of cancer. This review summarizes the role of integrin in tumor development and the current state of integrin inhibitors to provide a valuable reference for subsequent research.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Biological Products / Signal Transduction / Integrins / Cell Movement / Classification / Therapeutic Uses / Cell Proliferation / Drug Therapy Limits: Humans Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Biological Products / Signal Transduction / Integrins / Cell Movement / Classification / Therapeutic Uses / Cell Proliferation / Drug Therapy Limits: Humans Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2019 Type: Article