Your browser doesn't support javascript.
loading
Related Factors Affecting Long-term Prognosis of AML Children with Positive RUNX1-RUNX1T1 / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1767-1773, 2019.
Article in Chinese | WPRIM | ID: wpr-781399
ABSTRACT
OBJECTIVE@#To analyze the related factors affecting the long-term prognosis of acute myeloid leukemia (AML) children with positive RUNX1-RUNX1T1.@*METHODS@#The clinical data of 63 chlidren with positive RUNX1-RUNX1T1 AML treated by BCH-AML 05 regimen in our hospital from January 2010 to December 2015 were collected and analyzed retrospectively. The level of RUNX1-RUNX1T1 was detected at the time of initial diagnosis (T), after the first induction treatment (T), after the second induction treatment (T), after the first consolidation treatment (T), after the second consolidation treatment (T) and after the third consolidation treatment (T). According to the fusion transcript levels of RUNX1-RUNX1T1 the AML children were divided into low-expression group and high-expression group; the threshold values for grouping were 10 copies/10 β-glucuronidase (GUS), 10 copies/10 GUS, 10 copies/10 GUS, 10 copies/10 GUS, 1 copies/10 GUS and 0 copies respectively. The gained data were enrolled in the statistical analysis.@*RESULTS@#23 cases of 63 children died during the follow-up period, and the median follow-up time of the remaining 40 children were 30.04 (11-60) months. There were statistically significant differences in CD15 positive rate between low-expression group and high-expression group (P0.05). Univariate analysis showed that sex, Plt counts at T and fusion transcript levels at T, T and T correlated with the 5-year overall survival rate (P10 copies/10 GUS at T was an independent risk factor for 5-year overall survival rate (HR=2.13, 95%CI 1.04-7.78)(P<0.05).@*CONCLUSION@#The fusion transcript level after the first induction therapy in RUNX1-RUNX1T1-positive AML children is an independent factor influencing the long-term prognosis.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Leukemia, Myeloid, Acute / Oncogene Proteins, Fusion / Retrospective Studies / Core Binding Factor Alpha 2 Subunit / RUNX1 Translocation Partner 1 Protein Type of study: Observational study / Prognostic study / Risk factors Limits: Child / Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2019 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Leukemia, Myeloid, Acute / Oncogene Proteins, Fusion / Retrospective Studies / Core Binding Factor Alpha 2 Subunit / RUNX1 Translocation Partner 1 Protein Type of study: Observational study / Prognostic study / Risk factors Limits: Child / Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2019 Type: Article