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Literature Survey on Environmental Exposure to Antineoplastic Agents: / 医薬品情報学
Japanese Journal of Drug Informatics ; : 95-103, 2019.
Article in Japanese | WPRIM | ID: wpr-781887
ABSTRACT

Objective:

In late 1970s, occupational exposure to antineoplastic agents was reported. Various countries, including Japan, have published guidelines for handling antineoplastic agents. Surveys are still being conducted to determine the levels of environmental exposure to antineoplastic agents at individual hospitals, and incidents of contamination are often reported. This study provides details regarding a literature survey conducted to evaluate the actual state of environmental contamination by antineoplastic agents and identify the related issues in order to promote environmental monitoring.

Methods:

The literature search was carried out from January 1, 1990 to July 31, 2017. PubMed and Ichushi-Web were searched with the following keywordsantineoplastic agents,” “occupational exposure,” “surface contamination,” and “environmental monitoring.”

Results:

Following the literature search, 117 papers were included in the analysis. The findings showed that contamination by antineoplastic agents was widely reported in hospitals and places where antineoplastic drugs were not handled. The findings of this study regarding the actual state of environmental exposure are partial, as there is a lack of information on retail pharmacies and homes of outpatients who have received chemotherapy.

Discussion:

Therefore, further investigation is warranted. In addition, according to the current Japanese guidelines, published in 2015, environmental surveillance is not required to reduce contamination by antineoplastic agents. To promote environmental monitoring, we feel that it is necessary to determine a new survey method and the clarify optimum interval of environmental monitoring.

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Index: WPRIM (Western Pacific) Type of study: Prognostic study / Qualitative research Language: Japanese Journal: Japanese Journal of Drug Informatics Year: 2019 Type: Article

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Index: WPRIM (Western Pacific) Type of study: Prognostic study / Qualitative research Language: Japanese Journal: Japanese Journal of Drug Informatics Year: 2019 Type: Article