Meta-analysis on risk stratification of malignant ventricular tachyarrhythmic events in arrhythmogenic right ventricular cardiomyopathy / 영남의대학술지
Yeungnam University Journal of Medicine
;
: 208-215, 2017.
Article
in English
| WPRIM
| ID: wpr-787072
ABSTRACT
BACKGROUND:
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a cardiomyopathy characterized by predominant right ventricular fibro-fatty replacement, right ventricular dysfunction and ventricular arrhythmias. It is a rare but important cause of sudden cardiac death in children and young adults. A meta-analysis on risk stratification of major ventricular tachyarrhythmic events indicating the need for implantable cardioverter defibrillator therapy in ARVC was performed.METHODS:
The pubmed database was searched from its inception to May 2015. Of the 433 citations identified, 12 were included in this meta-analysis. Data regarding major ventricular tachyarrhythmic events were retrieved in 817 subjects from the studies. For the variables, a combined odds ratio (OR) was calculated using a fixed-effects meta-analysis.RESULTS:
Extensive right ventricular dysfunction (OR, 2.44), ventricular late potential (OR, 1.66), inducible ventricular tachyarrhythmia during electrophysiology study (OR, 3.67), non-sustained ventricular tachycardia (OR, 3.78), and history of fatal event/sustained VT (OR, 5.66) identified as significant risk factors (p < 0.0001).CONCLUSION:
This meta-analysis shows that extensive right ventricular dysfunction, ventricular late potential, inducible ventricular tachyarrhythmia during electrophysiological study, non-sustained ventricular tachycardia, and history of sustained ventricular tachycardia/fibrillation are consistently reported risk factors of major ventricular tachyarrhythmic events indicating implantable cardioverter defibrillator therapy in patients with ARVC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arrhythmias, Cardiac
/
Tachycardia
/
Odds Ratio
/
Risk Factors
/
Death, Sudden, Cardiac
/
Tachycardia, Ventricular
/
Ventricular Dysfunction, Right
/
Arrhythmogenic Right Ventricular Dysplasia
/
Death, Sudden
/
Defibrillators
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Child
/
Humans
Language:
English
Journal:
Yeungnam University Journal of Medicine
Year:
2017
Type:
Article
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