The functional connection of central executive network in patients with depression after clinical cure / 中华行为医学与脑科学杂志

ABSTRACT

Objective@#To study the changes in the functional connections of the central executive network in patients with depression after clinical cure.@*Methods@#Seventeen depression patients who met the clinical cure standard (patient group) and twenty-two healthy controls (control group) were selected.The baseline rs-fMRI data were collected from the healthy control group and the patient group respectively, and the rs-fMRI data in the patient group were collected again after 6 months.Compared the changes of central executive network function connection between the two groups.@*Results@#At baseline, there was a high functional connection in the left inferior parietal lobule(MNI x, y, z=-39, -69, 33)and right insula(MNI x, y, z=15, -45, 30) in the patient group compared with the control group.Compared with the baseline, there were high functional connections in part of the left inferior parietal lobe (MNI x, y, z=-60, -48, 21) and the right dorsolateral prefrontal lobe (MNI x, y, z=24, 18, 60), and low functional connections in part of the left inferior parietal lobe (MNI x, y, z=-51, -69, 18) in patient group 6 months after clinical cure.Compared with the control group, there was a high functional connection in the right dorsolateral prefrontal lobe (MNI x, y, z=45, 51, -6) and the right inferior parietal lobe (MNI x, y, z=42, -48, 27) in patient group 6 months after clinical cure.@*Conclusion@#The functional connection of central executive network of depression patients has not been restored, and the related abnormality is not stable in six months after reaching the clinical cure standard.