Effect of Modified Qingre Shenshi Tang on Inflammatory Factors, Oxidative Stress and Immune Function in Chronic Antral Sinusitis Patients with Damp-heat Pouring Downward Syndrome / 中国实验方剂学杂志

ABSTRACT

Objective:To explore effect of modified Qingre Shenshi Tang on inflammatory factors, oxidative stress and immune function in chronic antral sinusitis patients with damp-heat pouring downward syndrome. Method:A total of 94 cases of chronic antral sinusitis treated in our hospital from June 2017 to April 2018 were randomly divided into two groups, with 47 cases in each group. Control group was treated with metronidazole combined with gentamicin enema. In addition to the therapy of control group, the treatment group was given modified Qingre Shenshi Tang. The symptom scores, interleukin-2 (IL-2), IL-6, IL-8, tumor necrosis factor-α (TNF-α), gamma interferon (IFN-γ), super oxide dismutase (SOD), malondialdehyde (MDA), advanced oxidation protein products (AOPP), 8-hydroxy deoxyguanosine (8-OHDG), CD3+, CD4+, CD8+ levels of the two groups were observed before and after treatment, and the curative effect, reactions and relapse were observed. Result:After treatment, the total effective rates of treatment group(87.23%) and control group (78.72%) showed statistically significant differences (Z=2.067, PPα, IL-6, IL-8, MDA, AOPP, 8-OHDG, CD8+in the treatment group were lower than those in control group (Pγ, SOD, CD3+, CD4+, CD4+/CD8+were higher than those in control group (Pχ2=4.681, PConclusion:Modified Qingre Shenshi Tang has a good curative effect in the treatment of chronic antral sinusitis patients with damp-heat pouring downward syndrome by relieving symptoms, inhibiting inflammatory response, regulating oxidative stress, improving immune function and controlling recurrence rate.