An IgE-Mediated Allergic Reaction Caused by Mulberry Fruit
Allergy, Asthma & Immunology Research
; : 195-198, 2015.
Article
in En
| WPRIM
| ID: wpr-80636
Responsible library:
WPRO
ABSTRACT
Mulberry (Morus spp.) is a widespread deciduous tree and its fruit is commonly eaten in Korea and eastern Asia. Some reports demonstrate that mulberry fruit is a food allergen in the Mediterranean area. However, there has been no report of systemic allergic reactions after ingesting mulberry fruit in Korea. An 18-year-old boy with a mulberry fruit allergy visited our allergy clinic. He had experienced generalized urticaria, chest tightness, breathing difficulty, and abdominal cramping after ingesting mulberry fruit. The patient had a positive skin reaction to mulberry fruit extract (mean wheal size, 5 mm). We performed an ELISA to detect specific IgE antibody (Ab) to mulberry fruit extract in the patient's serum compared to those of non-atopic healthy controls and birch-sensitized individuals. Specific IgE Ab to mulberry fruit extract was detected in the patient's serum, as compared to non-atopic healthy controls. Another subject, who was strongly sensitized to birch pollen, also had a positive serum-specific IgE Ab to mulberry fruit. We performed IgE immunoblot analysis using the patient's and the other subject's sera, who had serum-specific IgE to mulberry fruit, to identify the IgE-binding component. An identical IgE-binding component to mulberry extract was detected in the two subjects at around 17 kDa, and which might be PR 10 of Bet v 1. In conclusion, mulberry fruit could induce a systemic allergic reaction through an IgE-mediated mechanism, and cross-reactivity might occur between mulberry fruit and birch pollen.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pollen
/
Respiration
/
Skin
/
Thorax
/
Trees
/
Urticaria
/
Immunoglobulin E
/
Enzyme-Linked Immunosorbent Assay
/
Colic
/
Betula
Limits:
Adolescent
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Allergy, Asthma & Immunology Research
Year:
2015
Type:
Article