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Molecular epidemiology of Norovirus infection among sporadic hospitalized adults with diarrhea in Qingdao, 2015 / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology ; (6): 104-107, 2017.
Article in Chinese | WPRIM | ID: wpr-808145
ABSTRACT
Objective@#To analyze the molecular epidemiology of Norovirus(NoV) infection among sporadic hospitalized adults with diarrhea in Qingdao, 2015.@*Methods@#Four hundred and nine stool samples were collected from hospitalized adults with diarrhea and detected by Real-time RT-PCR. For genotyping, ORF1 and ORF2 were partially amplified by RT-PCR and sequenced.@*Results@#18.1%(74/409) of stool samples were positive for NoV genogroup I(GI) (10/74) and genogroup II(G II) (64/74). Fifty-three positive samples of GII were sequenced and divided into 4 genotypes, including GII.Pe-GII.4(26/53), GII.P17-GII.17(19/53), GII.P12-GII.3(7/53) and GII.P16-GII.13(1/53). All GII.4 strains were the variants of GII.4-Sydney-2012. From May to Aug in 2015, GII.4 only accounted for 5.3%(1/19) and GII.17 were the major epidemic strains(68.4%, 13/19). But from Sept to Dec in 2015, GII.17 decreased substantially to 10.9%(6/55) and GII.4 became the most predominated strains (45.5%, 25/55).@*Conclusions@#NoV is an important pathogen responsible for viral diarrhea among adults in Qingdao. GII.4-Sydney-2012 and the newly variant GII.P17-GII.17 were the predominant epidemic strains in Qingdao, 2015.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Screening study Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Screening study Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2017 Type: Article