Synthesis and preliminary anti-diabetic activity evaluation of novel PEGylated GLP-1 receptor agonists / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 558-567, 2018.
Article
in Zh
| WPRIM
| ID: wpr-811757
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WPRO
ABSTRACT
@#In order to obtain glucagon-like peptide-1(GLP-1)analogs which can sustainedly control the levels of glucose, 12 derivatives were designed and synthesized by coupling monomethoxy polyethylene glycol(mPEG, with average molecular weights of 350, 550 and 750)to GLP-1 analogs. Preliminary pharmacological activities showed that all compounds retained GLP-1 receptor agonist activities, and the hypoglycemic activity of compound I-12 was similar to those of Ex-4 and Liraglutide, suggesting I-12 could be a potential long-acting GLP-1 receptor agonist.
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Language:
Zh
Journal:
Journal of China Pharmaceutical University
Year:
2018
Type:
Article