Triterpenoid saponins from the roots of Cyathula officinalis and their inhibitory effects on nitric oxide production / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 463-466, 2017.
Article
in En
| WPRIM
| ID: wpr-812093
Responsible library:
WPRO
ABSTRACT
The present study was designed to investigate the chemical constituents of the roots of Cyathula officinalis. Compounds were isolated by silica gel, Sephadex LH-20, ODS column chromatography, and preparative HPLC. Their structures were determined on the basis of 1D and 2D NMR techniques, mass spectrometry, and chemical methods. One new oleanane-type triterpenoid saponin, 28-O-[α-L-rhamnopyranosyl-(1→3)-β-D-glucuronopyranosyl-(1→3)-β-D-glucopyranosyl] hederagenin (1), was isolated from the roots of Cyathula officinalis. The anti-inflammatory activities of the isolates were evaluated for their inhibitory effects against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages cells. Compounds 2, 4, and 6 exhibited moderate anti-inflammatory activities.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Saponins
/
Triterpenes
/
Magnetic Resonance Spectroscopy
/
Cells, Cultured
/
Chemistry
/
Plant Roots
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Amaranthaceae
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Anti-Inflammatory Agents
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Nitric Oxide
Limits:
Animals
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2017
Type:
Article