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Expression of epithelial cell adhesion molecule and molecular subtypes and prognosis of breast cancer / 中南大学学报(医学版)
Zhongnan Daxue xuebao. Yixue ban ; (12): 258-263, 2016.
Article in Zh | WPRIM | ID: wpr-815044
Responsible library: WPRO
ABSTRACT
OBJECTIVE@#To investigate clinicopathological and prognostic significance of epithelial cell adhesion molecule (EpCAM) expression in breast cancer and its molecular subtypes.
@*METHODS@#The expression of EpCAM in 835 patients with breast invasive ductal carcinoma was detected by immunohistochemical Max VisionTM method, and its correlation with clinical pathological features and prognosis was analyzed.
@*RESULTS@#The positive expression of EpCAM was related to histological grade, lymph node metastasis, tumor size, clinical stage, the expression of estrogen receptor (ER), progesterone receptor (PR) and HER2 (P<0.05). The positive expression rates of EpCAM were 19.2%, 73%, 48.9%, 72.2%, and 62.1%, in Luminal A, Luminal B (HER2-), Luminal B(HER2+), HER2+, and triple-negative subtype, respectively. Log-rank test and univariate COX analysis showed that the EpCAM expression was associated with a poor prognosis in all patients (P<0.001), as well as the triple-negative subtype, luminal B subtype (HER2-), and HER2+ subtype (P<0.05). Multivariate COX analysis showed that EpCAM expression was associated with the survival in patients with the triple-negative or HER2+ subtype (P<0.05).
@*CONCLUSION@#EpCAM may be associated with progress of breast cancer. It is an independent prognostic factor in breast cancer, especially in the triple-negative and HER2+ subtypes.
Subject(s)
Full text: 1 Index: WPRIM Main subject: Prognosis / Breast Neoplasms / Receptors, Progesterone / Receptor, ErbB-2 / Epithelial Cell Adhesion Molecule / Lymphatic Metastasis Type of study: Prognostic_studies Limits: Humans Language: Zh Journal: Zhongnan Daxue xuebao. Yixue ban Year: 2016 Type: Article
Full text: 1 Index: WPRIM Main subject: Prognosis / Breast Neoplasms / Receptors, Progesterone / Receptor, ErbB-2 / Epithelial Cell Adhesion Molecule / Lymphatic Metastasis Type of study: Prognostic_studies Limits: Humans Language: Zh Journal: Zhongnan Daxue xuebao. Yixue ban Year: 2016 Type: Article