Effect of verapamil and nitroglycerin on transplanted lung function in canines / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 802-806, 2014.
Article
in Zh
| WPRIM
| ID: wpr-815526
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the protective effect of combined administration of verapamil and nitroglycerin on the function of canine transplanted lungs.@*METHODS@#Twenty orthotopic left lung transplantations were performed in 40 canines, which were randomly divided into 4 groups. In group I (control), the donor lungs were perfused and preserved with LPD solution, while group II with LPD solution plus verapamil 0.1 g/L, group III with LPD solution plus nitroglycerin 0.1g/L, and group IV with LPD solution plus verapamil 0.1 g/L and nitroglycerin 0.1 g/L. Hemodynamics and graft gas exchange were assessed 0, 2 and 4 h after the operation. The lung grafts were harvested to measure the wet/dry weight ratio, malondialdehyde (MDA) contents and superoxide dismutase (SOD) activity.@*RESULTS@#Compared with group I, II and III, the mean pulmonary artery pressure (MPAP), pulmonary vascular resistance index (PVRI), partial pressure of oxygen in arterial blood (PaO₂), dynamic compliance (Cdyn) and alveolar-arterial oxygen tension volume [P(A- a)O₂] in group IV were improved significantly (P0.05). In group IV, the wet/dry weight ratio and MDA contents were lower than those in the other 3 groups, and the SOD activity was significantly higher than that of the other 3 groups (P<0.05).@*CONCLUSION@#Verapamil and nitroglycerin in LPD solution can protect the respiratory function of canine lung grafts by attenuating pulmonary edema and oxidative stress.
Full text:
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Index:
WPRIM
Main subject:
Organ Preservation
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Pharmacology
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Blood Gas Analysis
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Verapamil
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Reperfusion Injury
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Lung Transplantation
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Nitroglycerin
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Protective Agents
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Hemodynamics
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Lung
Limits:
Animals
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2014
Type:
Article