Your browser doesn't support javascript.
loading
Efficacy and Safety of Aspirin Combined with Clopidogrel in the Treatment of Progressing Stroke :A Meta-analysis / 中国药房
China Pharmacy ; (12): 227-233, 2020.
Article in Chinese | WPRIM | ID: wpr-817367
ABSTRACT
OBJECTIVE:To sy stematically evaluate the efficacy and safety of a spirin combined with clopidogrel in the treatment of progressing stroke. METHODS :Retrieved from the Cochrane libraryPubMed,Embase,Clinical trials.gov ,CBM, VIP,Wanfang database and CNKI databases ,randomized controlled trials (RCTs)about aspirin combined with clopidogrel (trial group)versus aspirin or clopidogrel alone (control group )in the treatment of progressing stroke were collected. After literature screening and data extraction ,the quality of literatures were evaluated with bias risk assessment tool recommended by Cochrane system evaluator manual 5.2. Meta-analysis was performed by using Rev Man 5.3 software. RESULTS :A total of 27 RCTs involving 2 854 patients were enrolled. The results of Meta-analysis showed that response rate of trial group was significantly higher than aspirin group [RR =1.31,95%CI(1.26,1.37),P<0.000 01];Neurological deficit score (NDS)of trial group was significantly lower than control group [MD =-3.80,95%CI(-5.30,-2.30),P<0.000 01];National Institutes of Health Stroke Scale Score in trial group was significantly lower than aspirin group [MD =-3.72,95%CI(-5.25,-2.20),P<0.000 01] and clopidogrel group [MD =-2.44,95%CI(-4.14,-0.73),P=0.005]. Results of subgroup analysis showed that NDS score of trial group was significantly lower than control group after 14 d of treatment [MD =-2.19,95%CI(-3.11,-1.27),P<0.000 01],15 d of treatment [MD =-5.73,95%CI(-10.65,-0.81),P=0.02] and 28 d of treatment [MD =-3.45,95%CI(-4.24,-2.67),P< 0.000 01]. Compared with trial group ,there was no statistical significance in response rate with clopidogrel group ,the incidence of ADR with clopidogrel group ,the incidence of bleeding event with clopidogrel group ,and mortality with control group (P>0.05). CONCLUSIONS:Aspirin combined with clopidogrel in the ; treatment of progressive stroke ,can improve the efficacy and improve neurological deficit symptoms in the short term ,but can not reduce the incidence of ADR or the mortality during E-mail:wuyanzi89@126.com the treatment.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Practice guideline / Systematic reviews Language: Chinese Journal: China Pharmacy Year: 2020 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Practice guideline / Systematic reviews Language: Chinese Journal: China Pharmacy Year: 2020 Type: Article