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The Function and Regulatory Mechanism of TBK1 in Antiviral Innate Immunity / 中山大学学报(医学科学版)
Journal of Sun Yat-sen University(Medical Sciences) ; (6): 1-6, 2020.
Article in Chinese | WPRIM | ID: wpr-817625
ABSTRACT
@#TANK- binding kinase 1(TBK1)acts as the hub of antiviral innate immune signal transduction. On the one hand,TBK1 could be activated by a variety of pattern recognition receptors(PRR). On the other hand,as a critical kinase,activated TBK1 phosphorylates varieties of substrates,such as transcription factors interferon regulatory factor 3(IRF3)and IRF7 ,resulting in the initiation of antiviral innate immune responses. In this review ,we put emphasis on the TBK1 associated antiviral innate immune signaling ,as well as the regulation mechanisms of TBK1 expression and activation.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Sun Yat-sen University(Medical Sciences) Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Sun Yat-sen University(Medical Sciences) Year: 2020 Type: Article