Application of chimeric antigen receptor-regulatory T cell immunotherapy in organ transplantation / 器官移植
Organ Transplantation
;
(6): 547-2020.
Article
in Chinese
| WPRIM
| ID: wpr-825569
ABSTRACT
Regulatory T cell (Treg) is a subset of T cells that negatively regulates immunity and has the function of inhibiting rejection. The specific modification of Treg by chimeric antigen receptor (CAR) technology can successfully chime donor-specific antigen onto the surface of Treg, thus regulating the immune function of the body in a real-time manner. It provides a novel and promising therapeutic option for inducing immune tolerance. In this article, research progresses on Treg in immune related diseases, main difficulties in the realization of CAR-Treg technology and its role in inducing transplantation immune tolerance were reviewed, and the opportunities and challenges of CAR-Treg application in the field of organ transplantation are prospected.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Organ Transplantation
Year:
2020
Type:
Article
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