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Value of MiR-155 in Prognostic Evaluation of Elderly Patients with Primary Immune Thrombocytopenia / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1338-1343, 2020.
Article in Chinese | WPRIM | ID: wpr-827115
ABSTRACT
OBJECTIVE@#To explore the value of has-microRNA-155 (miR-155) in peripheral blood mononuclear cells (PBMNC) in prognostic evaluation of elderly patients with primary immune thrombocytopenia (PITP).@*METHODS@#One hundred and thirty elderly PITP patients and 60 healthy volunteers in our hospital were selected. The relative expression level of miR-155 in PBMNC was detected by RT-PCR. Unconditional logistic multivariate regression analysis was used to analyze the relationship between miR-155 expression and prognosis of PITP patients, and Kaplan-Meier was further used to analyze the relationship between miR-155 and PITP recurrence.@*RESULTS@#The relative expression level of miR-155 in PBMNC of elderly PITP patients was significantly higher than that in healthy volunteers, and increased significantly with the severity of the disease (P<0.05). The overall effective rate of elderly PITP patients with miR-155 low-expression was significantly higher than that in the patients with miR-155 high-expression (96.92% vs 72.31%) by after treatment with glucocorticoid. Multivariate analysis showed that miR-155 was an independent risk factor for PITP patients. Elderly patients with high expression of miR-155 showed a higher risk of recurrence.@*CONCLUSION@#miR-155 in PBMNC has a high accuracy for PITP diagnosis, and the elderly patients with high level of miR-155 show a poor prognosis and a higher risk of recurrence.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Leukocytes, Mononuclear / Biomarkers, Tumor / Purpura, Thrombocytopenic, Idiopathic / MicroRNAs / Kaplan-Meier Estimate / Neoplasm Recurrence, Local Type of study: Prognostic study Limits: Aged / Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Leukocytes, Mononuclear / Biomarkers, Tumor / Purpura, Thrombocytopenic, Idiopathic / MicroRNAs / Kaplan-Meier Estimate / Neoplasm Recurrence, Local Type of study: Prognostic study Limits: Aged / Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2020 Type: Article