Value of MiR-155 in Prognostic Evaluation of Elderly Patients with Primary Immune Thrombocytopenia / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1338-1343, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-827115
ABSTRACT
OBJECTIVE@#To explore the value of has-microRNA-155 (miR-155) in peripheral blood mononuclear cells (PBMNC) in prognostic evaluation of elderly patients with primary immune thrombocytopenia (PITP).@*METHODS@#One hundred and thirty elderly PITP patients and 60 healthy volunteers in our hospital were selected. The relative expression level of miR-155 in PBMNC was detected by RT-PCR. Unconditional logistic multivariate regression analysis was used to analyze the relationship between miR-155 expression and prognosis of PITP patients, and Kaplan-Meier was further used to analyze the relationship between miR-155 and PITP recurrence.@*RESULTS@#The relative expression level of miR-155 in PBMNC of elderly PITP patients was significantly higher than that in healthy volunteers, and increased significantly with the severity of the disease (P<0.05). The overall effective rate of elderly PITP patients with miR-155 low-expression was significantly higher than that in the patients with miR-155 high-expression (96.92% vs 72.31%) by after treatment with glucocorticoid. Multivariate analysis showed that miR-155 was an independent risk factor for PITP patients. Elderly patients with high expression of miR-155 showed a higher risk of recurrence.@*CONCLUSION@#miR-155 in PBMNC has a high accuracy for PITP diagnosis, and the elderly patients with high level of miR-155 show a poor prognosis and a higher risk of recurrence.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Leukocytes, Mononuclear
/
Biomarkers, Tumor
/
Purpura, Thrombocytopenic, Idiopathic
/
MicroRNAs
/
Kaplan-Meier Estimate
/
Neoplasm Recurrence, Local
Type of study:
Prognostic study
Limits:
Aged
/
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2020
Type:
Article
Similar
MEDLINE
...
LILACS
LIS