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A human circulating immune cell landscape in aging and COVID-19
Protein & Cell ; (12): 740-770, 2020.
Article in English | WPRIM | ID: wpr-828746
ABSTRACT
Age-associated changes in immune cells have been linked to an increased risk for infection. However, a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking. Here, we combined scRNA-seq, mass cytometry and scATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19. We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector, cytotoxic, exhausted and regulatory cells, along with increased late natural killer cells, age-associated B cells, inflammatory monocytes and age-associated dendritic cells. In addition, the expression of genes, which were implicated in coronavirus susceptibility, was upregulated in a cell subtype-specific manner with age. Notably, COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senescence. Therefore, these findings suggest that a dysregulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pneumonia, Viral / Mass Spectrometry / Aging / Gene Rearrangement / CD4-Positive T-Lymphocytes / Cytokines / Sequence Analysis, RNA / Coronavirus Infections / Gene Expression Regulation, Developmental / Cell Lineage Type of study: Prognostic study Limits: Adult / Aged / Aged80 / Humans Language: English Journal: Protein & Cell Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pneumonia, Viral / Mass Spectrometry / Aging / Gene Rearrangement / CD4-Positive T-Lymphocytes / Cytokines / Sequence Analysis, RNA / Coronavirus Infections / Gene Expression Regulation, Developmental / Cell Lineage Type of study: Prognostic study Limits: Adult / Aged / Aged80 / Humans Language: English Journal: Protein & Cell Year: 2020 Type: Article