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Comparison of ED of intranasal dexmedetomidine sedation in children with acyanotic congenital heart disease before and after cardiac surgery / 南方医科大学学报
Journal of Southern Medical University ; (12): 864-868, 2020.
Article in Chinese | WPRIM | ID: wpr-828892
ABSTRACT
OBJECTIVE@#To compare the median effective dose (ED) of intranasal dexmedetomidine for procedural sedation in uncooperative pediatric patients with acyanotic congenital heart disease before and after cardiac surgery.@*METHODS@#We prospectively recruited 47 children (22 in preoperative group and 25 in postoperative group) who needed sedation for transthoracic echocardiography (TTE). A modified up-and-down sequential study design was employed to determine dexmedetomidine dose for each patient with a starting dose of 2 μg/kg in both groups; dexmedetomidine doses for subsequent subjects were determined according to the responses from the previous subject using the up-and-down method at a 0.25 μg/kg interval. The ED was determined using probit regression. The onset time, examination time, wake-up time and adverse effects were measured, and the safety was evaluated in terms of changes in vital signs every 5 min.@*RESULTS@#The ED value of intranasal dexmedetomidine for sedation was 1.84 μg/kg (95% 1.68-2.00 μg/kg) in children with congenital heart disease before cardiac surgery, and 3.38 μg/kg (95% 3.21-3.54 μg/kg) after the surgery. No significant difference was found between the two groups in the demographic variables, onset time, examination time, wake-up time, or adverse effects.@*CONCLUSIONS@#In children with acyanotic congenital heart disease, the ED of intranasal dexmedetomidine for TTE sedation increases to 3.38 μg/ kg after cardiac surgery from the preoperative value of 1.84 μg/kg.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: General Surgery / Administration, Intranasal / Dexmedetomidine / Heart Defects, Congenital / Cardiac Surgical Procedures / Hypnotics and Sedatives Limits: Child / Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: General Surgery / Administration, Intranasal / Dexmedetomidine / Heart Defects, Congenital / Cardiac Surgical Procedures / Hypnotics and Sedatives Limits: Child / Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2020 Type: Article