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Coronavirus Disease 2019 Influenza A in Children: An Observational Control Study in China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 614-619, 2020.
Article in English | WPRIM | ID: wpr-828973
ABSTRACT
This study aimed to understand the differences in clinical, epidemiological, and laboratory features between the new coronavirus disease 2019 (COVID-2019) and influenza A in children. Data of 23 hospitalized children with COVID-19 (9 boys, 5.7 ± 3.8 years old) were compared with age- and sex-matched 69 hospitalized and 69 outpatient children with influenza A from a hospital in China. The participants' epidemiological history, family cluster, clinical manifestations, and blood test results were assessed. Compared with either inpatients or outpatients with influenza A, children with COVID-19 showed significantly more frequent family infections and higher ratio of low fever ( 39 °C), nasal congestion, rhinorrhea, sore throat, vomiting, myalgia or arthralgia, and febrile seizures. They also showed higher counts of lymphocytes, T lymphocyte CD8, and platelets and levels of cholinesterase, aspartate aminotransferase, lactate dehydrogenase, and lactic acid, but lower serum amyloid, C-reactive protein, and fibrinogen levels and erythrocyte sedimentation rate, and shorter prothrombin time. The level of alanine aminotransferase in children with COVID-19 is lower than that in inpatients but higher than that in outpatients with influenza A. Pediatric COVID-19 is associated with more frequent family infection, milder symptoms, and milder immune responses relative to pediatric influenza A.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Pneumonia, Viral / Virology / Blood / Case-Control Studies / Epidemiology / Coronavirus Infections / Allergy and Immunology / Influenza, Human / Pandemics Type of study: Observational study / Risk factors Limits: Child / Female / Humans / Male Language: English Journal: Biomedical and Environmental Sciences Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Pneumonia, Viral / Virology / Blood / Case-Control Studies / Epidemiology / Coronavirus Infections / Allergy and Immunology / Influenza, Human / Pandemics Type of study: Observational study / Risk factors Limits: Child / Female / Humans / Male Language: English Journal: Biomedical and Environmental Sciences Year: 2020 Type: Article