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Persistence of Denosumab Therapy among Patients with Osteoporosis
Asian Spine Journal ; : 453-458, 2020.
Article in 0 | WPRIM | ID: wpr-830848
Responsible library: WPRO
ABSTRACT
Results@#The study included 101 patients (84 females) with a median follow-up period of 23.6±14.2 months. The persistence rate declined to 85.3%, 78.3%, 74.1%, 71.3%, and 69.3% at 12, 24, 36, 48, and 60 months, respectively. Age at the initiation of denosumab therapy differed significantly between non-persistent (n=31) and persistent (n=70) patients (81.3 vs. 72.8 years, p <0.01). Persistence was significantly lower in patients aged ≥80 years than in those aged <60 and 60–79 years (both p <0.01). The reasons for non-persistence of denosumab therapy were transfer to another hospital (n=13), interruption of outpatient visits (n=11), dental treatment (n=4), adverse events (n=2), and patient request (n=1). @*Conclusions@#Persistence was significantly lower in patients aged ≥80 years than in patients of other ages, and strategies promoting persistence are needed for these elderly patients.
Full text: 1 Index: WPRIM Language: 0 Journal: Asian Spine Journal Year: 2020 Type: Article
Full text: 1 Index: WPRIM Language: 0 Journal: Asian Spine Journal Year: 2020 Type: Article