Your browser doesn't support javascript.
loading
Role of phosphoglycerate mutase 1 in the occurence and development of tumor / 上海交通大学学报(医学版)
Journal of Shanghai Jiaotong University(Medical Science) ; (12): 463-466, 2018.
Article in Chinese | WPRIM | ID: wpr-843739
ABSTRACT
Phosphoglycerate mutase 1 (PGAM1) as one of the most important enzymes for glycolysis pathway, is highly expressed in multiple tumor tissues and negatively correlated with the prognosis of cancer patients. PGAM1 catalyzes the conversion of 3-phosphoglycerate (3-PG) to 2-phosphoglycerate (2-PG) in glycolysis pathway, then promoting anabolic pathways, energy generation, and maintaining redox balance during cancer cell proliferation and metastasis. The small molecule PGAM1 inhibitors have emerged as a promising strategy for anti-tumor therapy. In this review, the significance of PGAM1 in tumor was reviewed and the research progress of PGAM1 inhibitors was also introduced.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Shanghai Jiaotong University(Medical Science) Year: 2018 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Shanghai Jiaotong University(Medical Science) Year: 2018 Type: Article