The effect of exogenous surfactant on the Eustachian tube function in the gerbil model of secretory otitis media / 西安交通大学学报·英文版

ABSTRACT

Objective: To investigate the effect of exogenous surfactant on Eustachian tube opening function. Methods: This reasarch measures for the Eustachian tube opening pressure by injection of surface active substance into middle ear space, studying the effect of surfactant on Eustachian tube opening function. Results: It has been showed that the injection of killed streptococcus pneumoneac bacteria by the transtympanic route, successfully developed a secretory otitis media model. Eustachian tube opening pressure in ears with SOM was significantly greater than those without effusion (P<0.01). Irrigation the middle ear space with surfactant resulted in a dramatic decrease in eustachian tube passive opening pressure in both normal and patients (P<0.01). Conclusion: The results indicate that flushing with exogenous surfactant by the transtympanic rote reduce of eustachian tube surface tension, and it benefits the Eustachian tube opening.