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The relationship between obesity and the prognosis-related factors of female breast cancer: A Meta-analysis / 肿瘤
Tumor ; (12): 1074-1080, 2013.
Article in Chinese | WPRIM | ID: wpr-848894
ABSTRACT

Objective:

To evaluate the relationship between obesity and prognosis-related factors in female patients with breast cancer.

Methods:

The high-quality cohort studies and case-control studies regarding obesity and the prognosis-related factors of breast cancer were identified by searching PubMed, Cochrane Library, Web of Science, China Academic Journals Full-text Database, Chinese Biological Medical Literature Database and Wanfang Data up to the December 2012. The Meta-analysis was conducted using RevMan5.0 software.

Results:

A total of 2 002 articles related to obesity and the prognostic factors of female breast cancer were searched out. Finally, 8 studies were included in this Meta-analysis by inclusion and exclusion criteria. The Meta-analysis revealed that the rates of lymph node metastasis (odds ratio 0.89, 95% confidence interval 0.85-0.93, P 2 cm (odds ratio 0.60, 95% confidence interval 0.42-0.85, P = 0.004) and pathological grade 3 tumor (odds ratio 0.88, 95% confidence interval 0.79-0.99, P = 0.003) were significantly different between the obesity group and non-obesity group. The subgroup analysis was performed in 6 studies with the same body mass index classification criterion and the prognostic factors. Three studies in English indicated that the rates of estrogen receptor-positive (odds ratio 0.63, 95% confidence interval 0.41-0.98, P = 0.04) and estrogen receptor-negative (odds ratio 1.58, 95% confidence interval 1.02-2.44, P = 0.04) were both significantly different between the obesity group and non-obesity group, but there were no significant relationships between obesity and the other prognostic factors.

Conclusion:

Current evidence indicates that obesity plays a negative role in the prognosis of female patients with breast cancer when the body mass index classification criterion is not considered. Obesity may exert different impacts on the prognosis of female patients with breast cancer in different countries or patients of different races when the subgroup analysis is conducted in the studies with the same body mass index classification criterion and the same prognostic factors. Copyright © 2013 by TUMOR.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Observational study / Prognostic study / Systematic reviews Language: Chinese Journal: Tumor Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Observational study / Prognostic study / Systematic reviews Language: Chinese Journal: Tumor Year: 2013 Type: Article