Research advance of PPARγ molecular and gene polymorphism / 解放军医学杂志

ABSTRACT

Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent nuclear transcription factor, which belongs to the type II nuclear hormone receptor superfamily. Ligand-activated PPARγ is involved in a variety of physiological and pathological processes such as the regulation of immune inflammation, lipid metabolism and glucose homeostasis. In recent years, it has been found that PPARγ gene polymorphism is closely related to the risk of infectious diseases, autoimmune diseases and metabolic diseases, indicating that PPARγ and its gene polymorphism may become potential diagnostic and therapeutic targets for many diseases. In present paper, the research progress of molecular structure, activity regulation, regulatory mechanism of immune inflammation and gene polymorphism of PPARγ are reviewed.