Role of swiprosin-l/efhd2 in regulating immune inflammatory response / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 162-166, 2020.
Article
in Zh
| WPRIM
| ID: wpr-857010
Responsible library:
WPRO
ABSTRACT
Swiprosin-1 (also known as EFhd2) is one of the earliest adaptor proteins found in T lymphocytes. Subsequent studies have found that it is also expressed on macrophages, B lymphocytes, mast cells and other immune cells, and affects the activation, migration, apoptosis and inflammatory response of immune cells, and participates in many signaling pathways 9uch as NF-kB, JAK-STAT, MAPK and calcium signaling. This arti cle briefly reviews the role and mechanism of EFhd2 reported in the regulation of immune inflammatory response in recent years, and provides a theoretical basis for further clarifying EFhd2 as a potential target for new immune regulation.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2020
Type:
Article