Study on mechanism of Mongolian medicine zhonglun-5 in anti-rheumatoid arthritis based on network pharmacology / 中国药理学通报

ABSTRACT

Aim To explore the mechanism of Mongolian medicine Zhonglun-5 in the treatment of rheumatoid arthritis via carrying out the network pharmacologyre-search. Methods Through various databases,we obtained the composition information and targets of Mongolian medicine Zhonglun-5, and perform multiple ana-lyses on these targets. Then, combined with theabove results,we concluded the significance of targets in anti-rheumatoid arthritis. Results Ninety targets for the treatment of rheumatoid arthritis with Mongolian medicine Zhonglun-5 were screened. The network analysis showed that Zhonglun-5 participated in 126 biological processes andgets 43 pathways for regulating RAS, FPAR,autopagy,JAK-STAT,tumor necrosis factor,etc. which were closely related with rheumatoid arthritis. It-was confirmed that the key targets of anti-rheumatoid arthritis were MAPK9, MAPK8, Aktl, MAPK14, STAT1, STAT3 and Bcl-2. Conclusions The therapeutic target of Mongolian medicine Zhonglun-5 is predicted by network pharmacology, which also reflected its multi-target and multi-channel characteristics, and provided a theoretical clue for the follow-up research anddevelopment of Zhonglun-5.