Effect of chicken collagen type II on collagen-induced arthritis in mice / 中国药理学通报

ABSTRACT

AIM: To investigate the effect of chicken collagen type II (C II) on collagen-induced arthritis (CIA) mice. METHODS: The model of mice CIA was prepared and the change of the mean of arthritis scores was observed. Meanwhile, ConA and LPS-induced, splenocytes proliferation and the production of interleukin (IL)-1 and IL-2 were measured. RESULT: CII [5, 10, 20 μg·kg-1ig × 7 d] significantly decreased the mean of arthritis scores, inhibited the increased ConA-induced splenocytes proliferation as well as the elevated production of IL-1 and IL- 2. Meanwhile, the pathological examination showed that articulus cartilage degeneration with synovial hyperplasia and inflammatory cells infiltration in CIA mice was suppressed by ig C II . CONCLUSION: C II has therapeutical effect on mice CIA which may be related to its immunoregulative function.