Review and Prospect of Drug Solid Dispersion Preparation Technology / 中国药学杂志

ABSTRACT

Solid dispersions provide an effective technical method for improving solubility and bioavailability of insoluble drugs. From its discovery to the present 60 years, 26 drug formulations have been approved by FDA. Moreover, the preparation technology of solid dispersion system has been continuously innovated and developed, such as electrospinning method, supercritical fluid method, spray freeze-drying technology and so on. In this paper, the development process of solid dispersion technology and carrier is reviewed, and the development of solid dispersion technology and carrier is summarized, and the existing problems are analyzed and prospected. It is expected to provide the reference for the research and development of drug solid dispersion.