Preparation of Oxcarbazepine Nanostructured Lipid Carriers and Their Physicochemical Properties / 中国药学杂志

ABSTRACT

OBJECTIVE: To prepare oxcarbazepine nanostructured lipid carriers (OXC-NLC), and investigate their physicochemical properties. METHODS: OXC-NLC was prepared by emulsification solvent evaporation method, and the optimum prescription was screened by orthogonal design. Scanning electron microscope was used to observe the morphology of OXC-NLC. Granulometer was applied to determine the particle size and distribution. DSC was adopted for phase analysis. RESULTS: OXC-NLC prepared under the optimum conditions was mostly spherical grains, with an average particle size of (63.04 ± 2.05) nm, which were distributed evenly, and the Zeta potential was (-33.52 ± 0.34) mV. DSC results indicated that the drug was dispersed in nanoparticles in an amorphous state, with entrapment efficiency of (98.16 ± 1.59)% and drug-loading capacity of (4.27 ± 0.70)%. The in vitro drug release was 27.31% in 8 h, which was followed by a sustained release. CONCLUSION: The prepared OXC-NLC has uniform particle size distribution, high encapsulation efficiency, and sustained release effect. This processing technology is simple, reliable, and highly reproducible.