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The outcome of the cervical cancer (stage Ib1) treated by radical surgery with and without neoadjuvant chemotherapy / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology ; : 2570-2575, 1999.
Article in Korean | WPRIM | ID: wpr-8604
ABSTRACT

OBJECTIVE:

The purpose of this retrospective study was to evaluate the effect of neoadjuvant chemotherapy followed by radical surgery compared with conventional radical surgery in stage Ib1 cervical cancer as to operative complications, the rate of lymph node metastasis, recurrence and overall five-year survival rates.

METHODS:

The study materal (98 cases of stage Ib1 cervical cancer) was divided into two groups; The one group was neoadjuvant chemotherapy (Cisplatin + 5-FU) followed by radical surgery (n = 41) and the other was the conventional radical surgery (n = 57) group. Reviewing records of operative and pathological reports and clinical findings, the outcome was statistically analyzed and compared.

RESULTS:

As to the complication, bladder dysfuntion was more frequent in neoadjuvant chemotherapy group, statistically significant.(43.9% vs 22.8%, P=0.034). No significant difference was found in the incidence of lymphnode metastasis (17% vs 17.5%, P=0.779) and overall five year survial rates(85.3% vs 87.7%, P=0.735).

CONCLUSION:

No benefical effect of neoadjuvant chemotherapy could be found on stage Ib1 cervical cancer in this retrospective study. However, well controlled longterm prospective study will be need to get firm conclusion.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Urinary Bladder / Uterine Cervical Neoplasms / Incidence / Survival Rate / Retrospective Studies / Drug Therapy / Lymph Nodes / Neoplasm Metastasis Type of study: Incidence study / Observational study / Prognostic study Language: Korean Journal: Korean Journal of Obstetrics and Gynecology Year: 1999 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Urinary Bladder / Uterine Cervical Neoplasms / Incidence / Survival Rate / Retrospective Studies / Drug Therapy / Lymph Nodes / Neoplasm Metastasis Type of study: Incidence study / Observational study / Prognostic study Language: Korean Journal: Korean Journal of Obstetrics and Gynecology Year: 1999 Type: Article