Clinical study of self-made Maju-Zhiyang Decoction combined with loratadine tablets for the children with atopic dermatitis and dampness and heat TCM syndrome / 国际中医中药杂志

ABSTRACT

Objective:To evaluate the clinical effect of self-made Maju-Zhiyang Decoction combined with loratadine tablets in the treatment of the children with atopic dermatitis and dampness-heat TCM syndrome. Methods:A total of 86 children with atopic dermatitis and dampness-heat syndrome in our hospital from January 2017 to May 2018 were selected and divided into two groups according to the random number table method, with 43 patients in each group. Patients in the control group were given loratadine tablets, while patients in the observation group were given self-made Maju-Zhiyang Decoction on this basis. Both groups were treated continuously for 2 weeks. The mossy lesion, scratch, exudative scab and erythema were evaluated before and after treatment. The severity of skin lesions was evaluated by Scoring Atopic Dermatitis Index (SCORAD). The multi-functional skin detector was used to detect transepidermal water loss (TEWL), the moisture content of the stratum corneum and the skin grease. The levels of IL-17, IL-33 and IgE were detected by double antibody sandwich ELISA. The adverse reactions during treatment were observed and recorded, and the clinical efficacy was evaluated. Results:The total effective rate was 93.0% (40/43) in the treatment group and 74.4% (32/43) in the control group, and the difference was statistically significant ( χ2=5.742, P<0.01). After treatment, the mossy, scratch, exudative scab, erythema scores and SCORAD scores in the observation group were significantly lower than those in the control group ( t values were 2.630, 8.779, 6.352, 5.264 and 9.115, respectively, P<0.01 or P<0.05), and the serum IL-17, IL-33 and IgE levels were significantly lower than those in the control group ( t values were 7.358, 19.285 and 135.049, respectively, all Ps<0.001). After treatment, the TEWL (9.77 ± 2.37 g/h?cm -2vs. 20.53 ± 3.89 g/h?cm -2, t=5.073) in the observation group was significantly lower than that of the control group ( P<0.01), the cuticle moisture content (27.16% ± 5.06% vs. 13.83% ± 2.71%, t=-8.552), and skin oil content (124.20 ± 3.29 g/cm 2vs. 90.17 ± 2.36 g/cm 2, t=-21.173) were significantly higher than those in the control group ( P<0.01). The incidence of adverse reactions in the treatment group was significantly lower than that of the control group ( χ2=9.437, P<0.05), which 4.7% (2/43) in the treatment group and 23.3% (2/43) in the control group. Conclusions:The self-made Maju-Zhiyang Decoction combined with loratadine tablets can alleviate the skin lesion symptoms of children with atopic dermatitis caused by dampness and heat, improve the skin barrier function, reduce the serum IL-17, IL-33 and IgE levels of children, and ensure the safety of drug use.