Retrospective clinical analysis of 133 cases of stage Ⅳ esophageal cancer / 中华放射肿瘤学杂志

ABSTRACT

Objective To investigate the clinical significance of radiotherapy for stage Ⅳ esophageal cancer.Methods Clinical data of 133 stage Ⅳ esophageal cancer patients admitted to our hospital from 2012 to 2018 were retrospectively analyzed.All patients were assigned into the radiochemotherapy (n=89)and chemotherapy groups (n=44).The survival analysis was performed by Kaplan-Meier method.The multivariate prognostic analysis was conducted by Cox's regression model.Results The 1-,2-and 3-year overall survival rates of the entire cohort were 53.5％,20.4％ and13.6％ respectively.Cox's regression analysis showed that gender,ECOG score,number of distant metastases,and whether the primary lesions received radiotherapy were the independent prognostic factors (all P＜0.05).The 1-,2-and 3-year survival rates in the radiochemotherapy group were 61％,29％ and19％,and 40％,4％,0％ in the chemotherapy group,respectively.In the radiochemotherapy group,the progression-free survival (PFS) and local progression-free survival (LPFS) were 8 months and 12.6 months,significantly longer compared with 4.7 months and 5.3 months in the chemotherapy group (both P＜0.05).The OS of patients receiving dose＞50Gy and ≤50Gy was 14.3 months and 8.2 months (P＜0.05),8.6 months and 2.8 months for the PFS (P＜0.05),and 15.2 months and 4.7 months for the LRFS (P＜0.05),respectively.The number of distant metastases and the clinical efficacy for primary lesions were the independent prognostic factors in the radiochemotherapy group (both P＜0.05).Conclusion Radiotherapy can improve the clinical prognosis of patients with stage Ⅳ esophageal cancer.