The effect of stimulation of the central thalamus on the expression of α1R in the prefrontal cortex after traumatic brain injury / 中华物理医学与康复杂志
Chinese Journal of Physical Medicine and Rehabilitation
; (12): 865-869, 2020.
Article
in Zh
| WPRIM
| ID: wpr-871231
Responsible library:
WPRO
ABSTRACT
Objective:To investigate the effect of stimulation of the central thalamus (CT-DBS) on awakening from coma after traumatic brain injury and the mechanisms involved.Methods:Forty-five healthy, adult Wistar rats were randomly assigned to either a blank control group, a sham stimulation or a stimulation group, each of 15. CT-DBS was applied in the stimulation group. Behavioral changes were observed, and the content of α1-adrenergic receptor (α1R) in the prefrontal cortex (PFC) was measured using immunofluorescence and western blotting.Results:The varus reflex was found in all 15 rats in the stimulation group, but in only 8 among the sham stimulation group. The average α1R content in the PFC was significantly higher in the stimulation group than in the sham stimulation group.Conclusions:CT-DBS can improve the level of consciousness after traumatic brain injury and promote awakening, at least in rats. The mechanisms may be related to the up-regulation of α1R expression in the PFC.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Physical Medicine and Rehabilitation
Year:
2020
Type:
Article