Expression of D-dimer in plasma of patients with colorectal cancer and its clinical significance / 肿瘤研究与临床

ABSTRACT

Objective:To investigate the plasma expression of D-dimer in patients with colorectal cancer and its correlation with clinicopathological characteristics of patients.Methods:The clinical data of 167 patients with colorectal cancer who were admitted to the First Hospital of Shanxi Medical University from January 2014 to March 2019 was retrospectively analyzed, and 54 patients without malignant tumors in the same period were selected as the control group. The expressions of plasma D-dimer and carcinoembryonic antigen (CEA) were detected by using immunoturbidimetry and electrochemiluminescence. Mann-Whitney U test was used to analyze the relationship between D-dimer expression and clinicopathological characteristics of patients. The relationship between D-dimer and CEA expressions was analyzed by Spearman correlation analysis. Results:The level of D-dimer [median ( P25, P75)] in the colorectal cancer group [323.0 ng/ml (150.0 ng/ml, 631.0 ng/ml)] was higher than that in the control group [142.0 ng/ml (89.3 ng/ml, 232.0 ng/ml)], and the difference was statistically significant ( Z=-4.374, P < 0.05). The level of D-dimer in patients with advanced colorectal cancer [401.0 ng/ml (167.5 ng/ml, 735.5 ng/ml)] was higher than that in patients with early stage [169.5 ng/ml (25.0 ng/ml, 325.3 ng/ml)], the difference was statistically significant ( Z = -4.569, P < 0.05); the level of D-dimer in the deterioration stage after treatment [382.0 ng/ml (175.0 ng/ml, 735.3 ng/ml)] was higher than that in the improvement stage after treatment [250.0 ng/ml (163.0 ng/ml, 391.0 ng/ml)], the difference was statistically significant ( Z = -2.731, P < 0.05); the level of D-dimer before operation [220.0 ng/ml (118.0 ng/ml, 446.5 ng/ml)] was lower than that after operation [320.0 ng/ml (184.5, 489.0 ng/ml)], the difference was statistically significant ( Z = -2.182, P < 0.05). There was a positive correlation between CEA and D-dimer expressions in colorectal cancer patients ( r = 0.509, P < 0.01). Conclusions:Elevated plasma D-dimer level may indicate advanced disease and poor prognosis. The plasma D-dimer level can be used as a predictor of therapeutic effect in patients with colorectal cancer.